Stability of Prostaglandin El and Dinoprostone (Prostaglandin E2) under Strongly Acidic and Basic Conditions
| Autor: | T.O. Oesterling, Randall G. Stehle |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Arrhenius equation
Acidic Region Chemistry medicine.medical_treatment Inorganic chemistry Pharmaceutical Science Prostaglandin Activation energy Dinoprostone chemistry.chemical_compound symbols.namesake Biochemistry Mole symbols medicine lipids (amino acids peptides and proteins) Prostaglandin E1 Prostaglandin E |
| Zdroj: | Journal of Pharmaceutical Sciences. 66:1590-1595 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600661123 |
| Popis: | The stability of prostaglandin El and dinoprostone was investigated at the extremes of the pH range (≤ 3 and ≥ 10) in the sequence prostaglandin E → prostaglandin A → prostaglandin B. The degradation rate is first order with hydrogen-ion and hydroxide-ion concentrations. Separation and analysis of the E prostaglandins were accomplished by TLC and UV spectrophotometry. At the lowest pH values and at elevated or low temperatures, significant amounts of 15-epiprostaglandin E were present. Apparent activation energies for the total dinoprostone loss, calculated from elevated temperature data, were 21 kcal/mole in the strongly acidic region and about 18 kcal/mole at pH 3. Corresponding studies in the alkaline region led to a derived Arrhenius activation energy of 15 kcal/mole with the appearance of significant amounts of 8-isoprostaglandin E. This difference in activation energies may reflect the different mechanisms operant at high and low pH values. |
| Databáze: | OpenAIRE |
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