Hetarylamidines derived from PtIV-mediated coupling of nitriles with aminoheterocycles

Autor:	Matti Haukka, Ali I. Uraev, V. Yu. Kukushkin, Dmitrii A. Garnovskii, E. D. Garnovskaya, Igor L. Eremenko
Rok vydání:	2006
Předmět:	chemistry.chemical_compound Nitrile chemistry Stereochemistry Infrared spectroscopy General Chemistry Nuclear magnetic resonance spectroscopy Mass spectrometry Coupling (probability) Medicinal chemistry Coupling reaction
Zdroj:	Russian Chemical Bulletin. 55:1631-1635
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-006-0465-y
Popis:	The trans-[PtCl4(EtCN)2] complex is involved in coupling reactions (CH2Cl2, 30–35 °C, 10–15 min) with 2-amino derivatives of heterocyclic compounds (2-NH2Het, where Het is pyridyl, 4-methylpyridyl, 5-methylpyridyl, 6-methylpyridyl, or thiazolyl) to form the trans-[PtCl4{ N(H)=C(Et)NHHet}2] complexes (1–5) with κ1(N)-coordinated hetarylamidine ligands. The reaction with the use of 2-aminopyrimidine (2-NH2Pym) produces the [PtCl4(2-NH2Pym)2] complex (6) as a result of complete replacement of the nitrile ligands in the [PtCl4(EtCN)2] complex. The compositions and structures of compounds 1–6 were confirmed by elemental analysis (C, H, N), IR spectroscopy, 1H, 13C{1H}, and 195Pt{1H} NMR spectroscopy, and FAB mass spectrometry. Complex 1 was additionally characterized by X-ray diffraction.
Databáze:	OpenAIRE
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