Ovulatory and Metabolic Effects of D-chiro-inositol in the Polycystic Ovary Syndrome
| Autor: | Geoffrey Allan, Daniela Jakubowicz, John E. Nestler, Ronald D. Gunn, Paula Reamer |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
D-chiro-Inositol business.industry Insulin medicine.medical_treatment media_common.quotation_subject Obstetrics and Gynecology General Medicine Placebo medicine.disease Polycystic ovary chemistry.chemical_compound Endocrinology Insulin resistance chemistry Oral administration Internal medicine medicine Hyperinsulinemia business Ovulation media_common |
| Zdroj: | Obstetrical & Gynecological Survey. 54:573-574 |
| ISSN: | 0029-7828 |
| DOI: | 10.1097/00006254-199909000-00018 |
| Popis: | Background Women with the polycystic ovary syndrome have insulin resistance and hyperinsulinemia, possibly because of a deficiency of a d-chiro-inositol–containing phosphoglycan that mediates the action of insulin. We hypothesized that the administration of d-chiro-inositol would replenish stores of the mediator and improve insulin sensitivity. Methods We measured steroids in serum and performed oral glucose-tolerance tests before and after the oral administration of 1200 mg of d-chiro-inositol or placebo once daily for six to eight weeks in 44 obese women with the polycystic ovary syndrome. The serum progesterone concentration was measured weekly to monitor for ovulation. Results In the 22 women given d-chiro-inositol, the mean (±SD) area under the plasma insulin curve after the oral administration of glucose decreased from 13,417±11,572 to 5158±6714 μU per milliliter per minute (81±69 to 31±40 nmol per liter per minute) (P=0.007; P=0.07 for the comparison of this change with the change in the placebo gr... |
| Databáze: | OpenAIRE |
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