Autor: |
Ian W. Kellaway, Mark A Phipps, Mokhtar M. El-Baseir |
Rok vydání: |
1997 |
Předmět: |
|
Zdroj: |
International Journal of Pharmaceutics. 151:145-153 |
ISSN: |
0378-5173 |
Popis: |
The encapsulation of nedocromil sodium and beclomethasone dipropionate with microspheres of poly( l -lactic acid) has been studied and preparation conditions optimised for entrapment efficiency and microsphere size suitable for inhalation. DSC was used to characterise the microspheres both in terms of drug/polymer interaction and influence of annealing conditions on the Tg and degree of crystallinity. The absence of molecular interaction was confirmed by FTIR. Incubation of the microspheres in phosphate buffer at 37°C for 8 days demonstrated no chemical degradation of the polymer as evidenced by IR spectral analysis and estimates of percentage crystallinity. Surface morphology (SEM) and internal structure (TEM) were consistent with a homogeneous degradation pattern. |
Databáze: |
OpenAIRE |
Externí odkaz: |
|