Alpha-glucosidase and alpha-amylase inhibiting thiodiketopiperazines from the endophytic fungus Setosphaeria rostrata isolated from the medicinal plant Costus speciosus in Sri Lanka
| Autor: | E. Dilip de Silva, Ryan M. Centko, Raymond J. Andersen, Stephen G. Withers, Pamoda B. Ratnaweera, Christina Tysoe |
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| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
0301 basic medicine biology Traditional medicine Plant Science Endophytic fungus biology.organism_classification 01 natural sciences Biochemistry Nmr data 03 medical and health sciences 030104 developmental biology Alpha-glucosidase Exserohilone Botany biology.protein Sri lanka Setosphaeria rostrata Alpha-amylase Agronomy and Crop Science Costus 010606 plant biology & botany Biotechnology |
| Zdroj: | Phytochemistry Letters. 22:76-80 |
| ISSN: | 1874-3900 |
| Popis: | Three new thiodiketopiperazine derivatives, rostratazine A (1) , rostratazine B (2) and rostratazine C (3) along with exserohilone (4) and boydine A (5) were isolated and identified from the laboratory culture of Setosphaeria rostrata , an endophytic fungus obtained from the fresh asymptomatic leaf tissues of the medicinal plant Costus speciosus from Sri Lanka. The structures of compounds 1–3 were elucidated on the basis of detailed interpretation of 1D- and 2D- NMR data and comparison to known compounds. Compounds 1 – 5 were subjected to α-glucosidase inhibitory and porcine pancreatic alpha amylase inhibitory assays and 4 showed alpha–glucosidase inhibitory activity while 2 showed porcine pancreatic alpha amylase inhibitory activity. |
| Databáze: | OpenAIRE |
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