Effect of aniracetam on monoaminergic brain systems in C57/bl mice

Autor:	K. S. Raevskii, P. M. Klodt, K. O. Eremin, V. S. Kudrin
Rok vydání:	2007
Předmět:	Homovanillic acid AMPA receptor Pharmacology Biochemistry Nootropic Aniracetam Cellular and Molecular Neuroscience chemistry.chemical_compound Monoamine neurotransmitter chemistry Dopamine Monoaminergic medicine Amphetamine Molecular Biology medicine.drug
Zdroj:	Neurochemical Journal. 1:70-73
ISSN:	1819-7132 1819-7124
DOI:	10.1134/s1819712407010096
Popis:	The effect of antiracetam (AN), a nootropic drug, which is one of the modulators of glutamate receptors of the AMPA type, in relation to amphetamine effects on locomotor activity as well as on the content of noradrenalin, dopamine, serotonin, and their metabolites in frontal cortex, hippocampus, hypothalamus, and striatum, was studied in C57/bl mice. AN, at a intraperitoneal dosage of 100 mg/kg, moderately decreased the locomotor activity of mice in comparison with the control. AN in combination with amphetamine did not significantly change the psychostimulating effect of the latter. The content of monoamines and their metabolites in the brain was not considerably changed after AN introduction. However, amphetamine-induced reduction of homovanillic acid and 5-hydroxyindolacetic acid in the brain was weakened by AN administration. It is proposed that the glutamate-dopaminergic intermediator interaction may be involved in the effect of AN.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c65b9d3c39cd7d470523f558401a04fd https://doi.org/10.1134/s1819712407010096 Zobrazit plný text záznamu Full text from SpringerLink