Characterization of a Glycyrrhizin-Deficient Strain of Glycyrrhiza uralensis

Autor:	Isao Fujii, Kazuo Ozaki, Hitoshi Watanabe, Munekazu Iinuma, Makio Shibano, Hiroaki Hayashi
Rok vydání:	2013
Předmět:	Pharmacology chemistry.chemical_classification biology Strain (chemistry) Chemistry Offspring Mutant Glycyrrhiza uralensis Saponin Glucuronidation Pharmaceutical Science General Medicine biology.organism_classification chemistry.chemical_compound Biochemistry Triterpene Glycyrrhizin
Zdroj:	Biological and Pharmaceutical Bulletin. 36:1448-1453
ISSN:	1347-5215 0918-6158
Popis:	A triterpene saponin, glucoglycyrrhizin, was isolated from a glycyrrhizin-deficient strain 83-555 of Glycyrrhiza uralensis (Leguminosae), and the structure was determined by chemical and spectral data to be 3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl]-glycyrrhetinic acid. Since this saponin has a 2'-O-β-D-glucopyranosyl moiety instead of the 2'-O-β-D-glucuronopyranosyl moiety of glycyrrhizin, the glucuronidation of 3-O-β-D-glucuronopyranosyl-glycyrrhetinic acid leading to glycyrrhizin is inhibited in this strain. All 4 offspring of the 83-555 strain produced glucoglycyrrhizin. Interestingly, 2 of the offspring produced both glycyrrhizin and glucoglycyrrhizin, and sequence analysis of the pkr gene suggested that these 2 offspring were hybrids of 83-555 strain and glycyrrhizin-producing strains.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c65b11a4578655658632a059bd5147c0 https://doi.org/10.1248/bpb.b13-00164 Zobrazit plný text záznamu