Spontaneous Incidence of Ocular Abnormalities in Laboratory Animals
| Autor: | Martin Bussieres, Brian C. Gilger, Cynthia S. Cook, Robert J. Munger, Michael H. Brown, Joshua T. Bartoe |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
Pediatrics medicine.medical_specialty 040301 veterinary sciences business.industry media_common.quotation_subject Incidence (epidemiology) 04 agricultural and veterinary sciences 030226 pharmacology & pharmacy 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Drug development Pharmacokinetics Incidence data Medicine business media_common |
| Zdroj: | Standards for Ocular Toxicology and Inflammation ISBN: 9783319783635 |
| DOI: | 10.1007/978-3-319-78364-2_4 |
| Popis: | This chapter provides incidence data on spontaneous ophthalmic abnormalities in the most commonly used species in toxicological and pharmacokinetic drug research. This data can be used to better differentiate test article-related ocular findings from background incidental lesions to enhance interpretation of ophthalmic findings, improve speed of drug development, reduce the number of studies that need to be repeated, and thus reduce the overall number of animals used in toxicology research and drug development. |
| Databáze: | OpenAIRE |
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