Fibroin-Alginate Scaffold for Design of Floating Microspheres Containing Felodipine
| Autor: | Pallavi Velapure, Harinath N. More, Shailesh Dugam, Prashant Rathod, Namdeo R. Jadhav |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Materials science Pharmaceutical Science Fibroin 02 engineering and technology Polymer 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Micromeritics 03 medical and health sciences 0302 clinical medicine Chemical engineering chemistry Spray drying Drug Discovery Mucoadhesion Dissolution testing Particle size Solubility 0210 nano-technology |
| Zdroj: | Journal of Pharmaceutical Innovation. 16:226-236 |
| ISSN: | 1939-8042 1872-5120 |
| Popis: | The objective of present work was to develop fibroin-sodium alginate floating microspheres of felodipine (FD) showing modified release. Binary polymer system of fibroin-sodium alginate was used to prepare microspheres by spray drying technique. Thus, FD loaded microspheres obtained were evaluated for % drug content, % entrapment efficacy, particle size, micromeritics, FT-IR, DSC, XRD, floatability profile, mucoadhesion, in vitro drug release, and accelerated stability studies. The drug content of FD-loaded microspheres (F1–F5) was in the range of 68.55 ± 1.20 to 78.21 ± 0.54 and entrapment efficacy 45.93 ± 0.41 to 61.60 ± 0.72%. The particle size varied from 60.33 ± 0.64 to 66.87 ± 0.85 μm. Acceptable Carr’s compressibility index and angle of repose demonstrated excellent flowability of microspheres (F1–F5). The FT-IR showed no chemical interactions between FD and polymers. The DSC and XRD indicated that FD was partially crystalline in microspheres. Floating parameters for optimized batch F2 were floating lag time10–15 s and floating time > 12 h. Floating buoyancy is 96.51 ± 0.66%. The in vitro drug dissolution kinetics of optimized F2 batch in 0.1NHCl and FSSGF demonstrated % drug release up to 80.42 ± 0.86% in 0.1NHCl and 84.64 ± 0.30% in FSSGF following Peppas model. Electrostatic repulsion between polymers successfully enabled the design of FD-loaded floating microspheres by spray drying. Excellent floating profile and extended release for 12 h, as per USFDA guidelines, have been demonstrated by the fibroin-sodium alginate binary composite system. In the future, fibroin-sodium alginate scaffold can be successfully used for tailor-made floating and release profiles of drugs belonging to different solubility classes. |
| Databáze: | OpenAIRE |
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