Signs of mental confusion and asterixis in hypercapnic COPD patients are attributable to elevated blood levels of ammonia

Autor: Vlasios Skopas, Nikolaos Koulouris, Stylianos A. Michaelides, Avgerinos-Romanos Michailidis, Nikolaos Trakas, George Bablekos
Rok vydání: 2018
Předmět:
Zdroj: Clinical Problems.
DOI: 10.1183/13993003.congress-2018.pa4059
Popis: Given that signs of mental confusion (MC) and asterixis (AS) are usually encounterd in patients with liver failure (LF) we investigated the relation between presence of MC & AS in hypercapnic COPD patients and their blood levels of ammonia (BLA). We studied 44 patients with hypercapnic respiratory failure due to COPD (31 male and 13 female) aged 67.3±4.3 yrs. (mean±SD) with a mean PCO2 of 59.4±6.2 mmHg (range 48.2 - 71.8) by recording the presence of MC & AS on admission while simulataneously measuring their BLA by Conway9s microdiffusion method (CMM). Since CMM has fluctuating results we performed several measurements for each patient and used their mean values for statistical evaluation. From all patients 29 (Group A) presented MC and or AS while the rest 15 (Group B) did not. BLA in Group A were 76.5± 15.7 μg/dl while in Group B were 37,6 ± 9.2 μg/dl. Group A exhibited an increased BLA than Group B by 38,9 μg (almost double the value of Group B) and this difference was statistically signifigant (Student9s t-test, p
Databáze: OpenAIRE