Acetals of lactams and acid amides. 36. Some reactions of enamines of the isoquinoline series and synthesis of pyrimido[4,3-a]isoquinolines

Autor:	V. G. Granik, V. F. Knyazeva, N. P. Solov'eva, I. V. Persianova, R. G. Glushkov
Rok vydání:	1982
Předmět:	chemistry.chemical_compound Primary (chemistry) Chemistry Phosphorus Organic Chemistry Dimethylformamide chemistry.chemical_element Organic chemistry Isoquinoline Dimethylacetamide
Zdroj:	Chemistry of Heterocyclic Compounds. 18:838-842
ISSN:	1573-8353 0009-3122
DOI:	10.1007/bf00506592
Popis:	The reactions of 1-methylene-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives with acyl chlorides were investigated. 2-Oxopyrimido[4,3-a]isoquinoline derivatives were obtained by the reaction of 1-carbamidomethylene-6,7-dimethoxy-1,2, 3,4-tetrahydroisoquinoline with dimethylformamide and dimethylacetamide diethylacetals. The reaction of the latter with phosphorus oxychloride and then with primary amines was used to synthesize a number of hydrochlorides that are derivatives of 2-iminopyrimido[4,3-a]isoquinoline.
Databáze:	OpenAIRE
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