Synthesis and biological activity of new hybrids compounds derived from benzofuroxanes and polyene antibiotics
| Autor: | Vladimir V. Zobov, I. S. Sazykin, Elena Chugunova, M. I. Khammami, N. V. Kulik, Alexander R. Burilov, M. A. Sazykina, R. E. Mukhamatdinova, Nurgali Akylbekov |
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| Rok vydání: | 2016 |
| Předmět: |
biology
010405 organic chemistry medicine.drug_class Stereochemistry Antibiotics Biological activity General Chemistry biology.organism_classification Polyene 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Nystatin chemistry Amphotericin B medicine Organic chemistry Trichophyton medicine.drug Hybrid |
| Zdroj: | Russian Journal of General Chemistry. 86:1037-1040 |
| ISSN: | 1608-3350 1070-3632 |
| DOI: | 10.1134/s1070363216050091 |
| Popis: | Hybrid compounds based on 4,6-dichloro-5-nitrobenzofuroxan, 7-chloro-4,6-dinitrobenzofuroxan, 5,7-dichloro-4,6-dinitrobenzofuroxan, and polyene antibiotics (amphotericin B and nystatin) have been prepared for the first time. They have exhibited biological activity comparable to that of starting antibiotics. Activity of the compound derived from 5,7-dichloro-4,6-dinitrobenzofuroxan and nystatin towards Trichophyton mentagrophytes is 4 times higher than that of nystatin. |
| Databáze: | OpenAIRE |
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