| Autor: |
Ken-Edwin Aryee, Leonard D Shultz, Lisa M Burzenski, Dale L Greiner, Michael A Brehm |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Leukocyte Biology. 113:418-433 |
| ISSN: |
1938-3673 |
| DOI: |
10.1093/jleuko/qiac020 |
| Popis: |
Agents that induce inflammation have been used since the 18th century for the treatment of cancer. The inflammation induced by agents such as Toll-like receptor agonists is thought to stimulate tumor-specific immunity in patients and augment control of tumor burden. While NOD-scid IL2rγnull mice lack murine adaptive immunity (T cells and B cells), these mice maintain a residual murine innate immune system that responds to Toll-like receptor agonists. Here we describe a novel NOD-scid IL2rγnull mouse lacking murine TLR4 that fails to respond to lipopolysaccharide. NSG-Tlr4null mice support human immune system engraftment and enable the study of human-specific responses to TLR4 agonists in the absence of the confounding effects of a murine response. Our data demonstrate that specific stimulation of TLR4 activates human innate immune systems and delays the growth kinetics of a human patient-derived xenograft melanoma tumor. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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