Autor: | Paul L. Martin, Russell H. Wiesner, William M. Lee, A. Obaid Shakil, Marion G. Peters, Rise Stribling, Eugene R. Schiff, Elizabeth Murphy, E Atillasoy, Kent G. Benner, Steven Han, Anne M. Larson, Timothy M. McCashland, Timothy J. Davern, Nathan M. Bass, Tom Faust, Chris E. Freise, Cary Caldwell, Andres T. Blei, Hsichao Chow, George Ostapowicz, Robert J. Fontana, Jorge Rakela, Smita Rouillard, Steven L. Flamm, Henry C. Bodenheimer, Thomas D. Schiano, Umesh Masharani, Lawton Shick, J. Eileen Hay, Jeffrey S. Crippin |
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Rok vydání: | 2000 |
Předmět: |
Toxic hepatitis
Liver injury medicine.medical_specialty Physiology business.industry Fulminant medicine.medical_treatment Gastroenterology Hepatotoxin Troglitazone Liver transplantation medicine.disease Bioinformatics Endocrinology Fulminant hepatic failure Internal medicine medicine medicine.symptom Adverse effect business medicine.drug |
Zdroj: | Digestive Diseases and Sciences. 45:549-553 |
ISSN: | 0163-2116 |
Popis: | The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury. Thus, troglitazone should be prescribed with caution and should not be used as a first-line agent in the treatment of type II DM when potentially less toxic alternatives are available. It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone. Other thiazolidinediones currently in clinical trials may be able to provide the therapeutic benefits of troglitazone without significant hepatotoxicity. If troglitazone is used, frequent monitoring of serum aminotransferases and symptoms is mandatory. However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable. Thus, the value of close monitoring and when, if ever, it is safe to stop such monitoring are currently unclear. |
Databáze: | OpenAIRE |
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