Synthesis and biological evaluation of isoflavone analogues from Dalbergia oliveri

Autor:	Soazig Douillard, Udom Kokpol, Jean-Pierre Finet, Nicolas Vidal, Sébastien Combes, Vincent Peyrot, Warinthorn Chavasiri, Sujittra Deesamer
Rok vydání:	2007
Předmět:	biology Stereochemistry Chemistry Organic Chemistry biology.organism_classification Antimicrobial Biochemistry In vitro Drug Discovery Fusarium oxysporum Cytotoxic T cell Dalbergia oliveri Antibacterial activity Cytotoxicity IC50
Zdroj:	Tetrahedron. 63:12986-12993
ISSN:	0040-4020
Popis:	Mucronulatol 1 and violanone 2 isolated from Dalbergia oliveri Gamble, and the corresponding isoflavone 3 were prepared by ligand coupling reactions involving organolead reagent. Biological studies have shown a significant cytotoxic effect against an HBL100 leukemia cell line only for isoflavan 1 with an IC50 value amounting to 5.7 μM. All the drugs modestly inhibit the in vitro microtubule assembly, independently of the cytotoxic ability. Natural compounds 1 and 2 have no antibacterial activity, but are potent inhibitors of the Fusarium oxysporum phytopathogenic fungal growth.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c504f9a92488a7fb118559fcf4ea1854 https://doi.org/10.1016/j.tet.2007.10.030 Zobrazit plný text záznamu Full Text from ScienceDirect