Assessing the reliability of ecotoxicological studies: An overview of current needs and approaches
| Autor: | Amy Beasley, Keith R. Solomon, Holly Zahner, Marion Junghans, Ryszard Laskowski, Caroline T. A. Moermond, Roger L. Breton |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Engineering business.industry media_common.quotation_subject Geography Planning and Development General Medicine 010501 environmental sciences 01 natural sciences Hazard Weighting Reliability engineering 03 medical and health sciences 030104 developmental biology Risk analysis (engineering) Quality (business) Environmental impact assessment Good laboratory practice business Risk assessment Categorical variable Reliability (statistics) 0105 earth and related environmental sciences General Environmental Science media_common |
| Zdroj: | Integrated Environmental Assessment and Management. 13:640-651 |
| ISSN: | 1551-3777 |
| Popis: | In general, reliable studies are well designed and well performed, and enough details on study design and performance are reported to assess the study. For hazard and risk assessment in various legal frameworks, many different types of ecotoxicity studies need to be evaluated for reliability. These studies vary in study design, methodology, quality, and level of detail reported (e.g., reviews, peer-reviewed research papers, or industry-sponsored studies documented under Good Laboratory Practice [GLP] guidelines). Regulators have the responsibility to make sound and verifiable decisions and should evaluate each study for reliability in accordance with scientific principles regardless of whether they were conducted in accordance with GLP and/or standardized methods. Thus, a systematic and transparent approach is needed to evaluate studies for reliability. In this paper, 8 different methods for reliability assessment were compared using a number of attributes: categorical versus numerical scoring methods, use of exclusion and critical criteria, weighting of criteria, whether methods are tested with case studies, domain of applicability, bias toward GLP studies, incorporation of standard guidelines in the evaluation method, number of criteria used, type of criteria considered, and availability of guidance material. Finally, some considerations are given on how to choose a suitable method for assessing reliability of ecotoxicity studies. Integr Environ Assess Manag 2017;13:640-651. © 2016 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC). |
| Databáze: | OpenAIRE |
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