Genetic clues to the etiology of Balkan endemic nephropathy: Investigating the role of ACE and AT1R polymorphisms

Autor:	Ivana Novakovic, Danica Bukvić, Zorica Krcunovic, Nela Maksimovic, Slavenka Janković, Sanja Simic-Ogrizovic, Dragana Cvetković, Ljubica Djukanovic
Rok vydání:	2010
Předmět:	Genetics Study groups Balkan endemic nephropathy Healthy individuals Genotype Etiology medicine Disease Biology General Agricultural and Biological Sciences medicine.disease General Biochemistry Genetics and Molecular Biology
Zdroj:	Archives of Biological Sciences. 62:957-965
ISSN:	1821-4339 0354-4664
DOI:	10.2298/abs1004957k
Popis:	Balkan endemic nephropathy (BEN) was recognized as a distinct entity more than 50 years ago, but the exact environmental and genetic causes of the disease remain elusive. Considering the role of the renin-angiotensin system (RAS) in the emergence of various nephropathies, in the present study we evaluated the possible association with BEN of polymorphisms in two RAS genes: I/D ACE (an angiotensin-converting enzyme) and A1166C AT1R (an angiotensin type 1 receptor). The study groups consisted of 48 BEN patients from the endemic region in the district of Kolubara, Serbia, 33 patients with other nephropathies and 42 healthy individuals. The ACE DD genotype was significantly more represented in the NBEN group (OR=5.447; 95%CI=1.862-15.932, p
Databáze:	OpenAIRE
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