Bioverfügbarkeit von Isosorbiddinitrat und Isosorbid-5-mononitrat unter Steady-state-Bedingungen

Autor:	J. Knoll, G. Menke, P.-G. Merz, N. Rietbrock
Rok vydání:	2008
Předmět:	Delayed-Action Preparations Sustained-Release Preparations Chemistry Isosorbide-5-mononitrate Significant difference medicine General Medicine Steady state (chemistry) Pharmacology Isosorbide dinitrate Crossover study medicine.drug Bioavailability
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 110:1821-1825
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1069095
Popis:	The relative bioavailability of isosorbide dinitrate (ISDN) and its mononitrate metabolites (IS-2-MN, IS-5-MN) was determined under repetitive dose conditions in 8 healthy volunteers using a randomised, crossover design. Reference drugs were non-sustained release ISDN (Isoket 20) and IS-5-MN (Ismo 20). The relative bioavailability of ISDN after Iso Mack Retard was 69%, for two development products 78% and 79%, and 87% for Isoket Retard. The bioavailability of IS-2-MN and IS-5-MN in sustained release preparations was 6-16% and 1-17% lower, respectively. Whereas the sum total for the area under the concentration-time curve (ISDN and metabolites) for Iso Mack Retard 20 mg was also significantly lower, there was no significant difference in this parameter between Isoket retard 20 and Isoket 20. Taking IS-5-MN non-retard as reference, the bioavailability of IS-5-MN and total nitrate in all ISDN preparations examined was significantly lower.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c4b45827022dec98b9b10180afdc4e25 https://doi.org/10.1055/s-2008-1069095 Zobrazit plný text záznamu