| Autor: |
Stanley Stein, Jonglin Tsao, Jodi Fausnaugh, Yon Ebright, Guillermo Tous |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
Journal of Liquid Chromatography. 11:2005-2017 |
| ISSN: |
0148-3919 |
| Popis: |
A procedure is described for the purification of synthetic methylphosphonate oligodeoxyribo-nucleosides. Syntheses were done on an automated instrument with the trityl group on in the last cycle. The oligomers were manually cleaved from the solid support and purified by reverse-phase HPLC in order to remove shorter fragments produced during incomplete couplings. After detritylation, the oligomers were repurified by reverse-phase HPLC. Typically, an overall yield of 25% or more was obtained. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
