| Autor: |
Richard M. Ransohoff, Ann Chernosky, Kimberly Krivacic, Marie Tani, Andrzej Glabinski, Hsiung Fei Chien, John W. Peterson, Bruce D. Trapp |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Methods in Enzymology ISBN: 9780121821883 |
| DOI: |
10.1016/s0076-6879(97)87023-1 |
| Popis: |
Publisher Summary Chemokines are proposed to play a role in CNS inflammatory disease at this stage of leukocyte recruitment. In this sense, chemokines exert an essential function in the development of immune-mediated CNS inflammation. This concept is supported by several studies of CNS chemokine expression during experimental autoimmune encephalomyelitis (EAE), all of which indicate an intimate relationship between chemokine expression and clinical disease. Further, antibodies to one chemokine macrophage inflammatory protein-1α, reduces the severity of passive-transfer EAE. Inflammatory cells enter nervous system tissues in virtually all pathological states, with the character of the infiltrate differing widely, according to the pattern of tissue injury. This chapter studies chemokine production in the CNS during several models of nervous system pathology. These studies, in aggregate, begin to sketch an intriguing relationship between the preferential expression of individual chemokines and the recruitment of specific leukocyte cell types to the CNS or peripheral nervous system (PNS) compartment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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