Hydrolysis and acylation of imino group in E/Z-isomers of 3,4-dialkyl-8-amino-1-imino-6-morpholin-4-yl-2-oxa-7-azaspiro[4.4]nona-3,6,8-triene-9-carbonitriles

Autor:	K. V. Lipin, Oleg V. Ershov, Sergey V. Fedoseev, Oleg E. Nasakin, M. Yu. Belikov, I. V. Lipovskaya
Rok vydání:	2013
Předmět:	NMR spectra database Acylation Hydrolysis chemistry.chemical_compound chemistry Stereochemistry Morpholine Organic Chemistry Acetamide
Zdroj:	Russian Journal of Organic Chemistry. 49:1195-1198
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428013080162
Popis:	Acid-catalyzed hydrolysis of 3,4-dialkyl-substituted 8-amino-1-imino-6-morpholin-4-yl-2-oxa-7-azaspiro[4.4]nona-3,6,8-triene-9-carbonitriles under mild conditions led to the formation of 8-amino-6-morpholin-4-yl-1-oxo-2-oxa-7-azaspiro[4.4]nona-3,6,8-triene-9-carbonitriles, and their acylation afforded N-(8-amino-9-cyano-6-morpholin-4-yl-2-oxa-7-azaspiro-[4.4]nona-3,6,8-trien-1-ylidene)acetamides. The NMR spectra of compounds synthesized in contrast to the spectra of initial N-unsubstituted imins contained no doubled proton and carbon signals.
Databáze:	OpenAIRE
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