Head-to-head comparison of 1-week triple regimens combining ranitidine or omeprazole with two antibiotics to eradicate Helicobacter pylori

Autor:	M. Pivari, G Bisso, Sergio Vigneri, Maria Raffaella Mele, Carlo Mansi, R. Termini, Vincenzo Savarino, Guido Celle, Patrizia Zentilin, G. S. Mela
Rok vydání:	1999
Předmět:	medicine.medical_specialty Hepatology biology medicine.drug_class business.industry Spirillaceae Antibiotics Gastroenterology Proton-pump inhibitor Helicobacter pylori biology.organism_classification Surgery Ranitidine Clarithromycin Internal medicine medicine Pharmacology (medical) business Omeprazole medicine.drug Antibacterial agent
Zdroj:	Alimentary Pharmacology & Therapeutics. 13:643-649
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.1999.00522.x
Popis:	Background : Triple therapies containing omeprazole and ranitidine have been shown to be equivalent in eradicating H. pylori infection, but have been assessed either separately or head-to-head, only in small trials. Aim : To carry out a large randomized controlled study comparing omeprazole and ranitidine combined with two antibiotic combinations for 1 week. Methods : Three hundred and twenty H. pylori-positive patients were randomly subdivided into four equal-sized groups and received one of the following treatments: OAM = omeprazole 20 mg b.d. + amoxycillin 1 g b.d. + metronidazole 500 mg b.d.; RAM = ranitidine 300 mg b.d. + amoxycillin 1 g b.d. + metronidazole 500 mg b.d.; OAC = omeprazole 20 mg b.d. + amoxycillin 1 g b.d. + clarithromycin 250 mg t.d.s.; RAC=ranitidine 300 mg b.d. + amoxycillin 1 g b.d. + clarithromycin 250 mg t.d.s. The assessment of H. pylori status was performed before and 4 weeks after the end of therapy by means of CLO-test and histology. H. pylori infection was considered to be eradicated when both tests were negative. Results : OAM and RAM eradicated H. pylori in 89% and 85% of cases on per protocol (P = 0.48) and in 77% and 75% of cases on intention-to-treat analyses (P = 0.71). OAC and RAC eradicated H. pylori in 67% and 70% of cases on per protocol (P = 0.68) and in 57% and 64% of cases on intention-to-treat analyses (P = 0.41). In contrast, there was significant difference between OAM and OAC (P
Databáze:	OpenAIRE
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