An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UVB-inflamed and normal skin

Autor:	Charles Locke, Peter W. Reeh, W. Rachel Duan, Ahmed A. Othman, Klaus Schaffler, Connie R. Faltynek, Wolfram Nothaft, Andrea E. Best
Rok vydání:	2013
Předmět:	Pharmacology integumentary system Laser-Evoked Potentials business.industry Antagonist TRPV1 Placebo Nociception Anesthesia Hyperalgesia Medicine Pharmacology (medical) Tramadol medicine.symptom business Etoricoxib medicine.drug
Zdroj:	British Journal of Clinical Pharmacology. 75:404-414
ISSN:	0306-5251
DOI:	10.1111/j.1365-2125.2012.04377.x
Popis:	Aims Laser (radiant-heat) evoked potentials (LEPs) from vertex-EEG peak-to-peak (PtP) amplitude were used to determine acute antinociceptive/antihyperalgesic efficacy of ABT-102, a novel TRPV1 antagonist efficacious in preclinical pain models, compared with active controls and placebo in normal and UVB-inflamed skin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c3512370321050a2147fbafccf5e6a4c https://doi.org/10.1111/j.1365-2125.2012.04377.x Zobrazit plný text záznamu Plný text