Differences in the Brain Cortical Thickness and Area of Different Lobes Between Fetuses with Intrauterine Growth Restriction and Controls Based on 3-Tesla Magnetic Resonance Imaging (MRI)
| Autor: | Zohreh Alibeigi Nezhad, Mohammad Ali Kazemi, Nazanin Seyed Saadat, Hassan Hashemi, Behnaz Moradi, Mahboobeh Shirazi, Masoumeh Gity, Hossein Ghanaati, Maryam Rahmani |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Fetus Cerebellum 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Hippocampus Intrauterine growth restriction Magnetic resonance imaging Insular cortex medicine.disease Temporal lobe 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Endocrinology Internal medicine Temporal lobe/cortex medicine Radiology Nuclear Medicine and imaging 030212 general & internal medicine business |
| Zdroj: | Iranian Journal of Radiology. 18 |
| ISSN: | 2008-2711 1735-1065 |
| DOI: | 10.5812/iranjradiol.106888 |
| Popis: | Background: Intrauterine growth restriction (IUGR) is a major factor in long-term perinatal morbidity and is associated with abnormal fetal brain development; however, its pattern of brain involvement remains unknown. Objectives: This study aimed to investigate the effect of IUGR on the brain parenchyma. Patients and Methods: Forty-two women with IUGR pregnancy and 28 women with normally grown fetuses at 28 - 38 weeks of pregnancy underwent 3-tesla magnetic resonance imaging (MRI). Cortical thickness was assessed in four regions and corrected by the biparietal diameter/2. Also, the whole brain surface area (WBA) was measured, and the areas of six brain regions were calculated and corrected by WBA. Results: In the IUGR group, the cortical thickness in the insula and temporal lobe was significantly thinner than the control group (0.034 vs. 0.043 and 0.036 vs. 0.047, respectively; P < 0.05); these fetuses also showed significantly reduced WBA (P = 0.028). The corrected brain areas were not significantly different between the groups, except for the corrected areas of the cerebellum and the hippocampus, which increased in the IUGR group as compared to the control group (0.147 vs. 0.130 and 0.017 vs. 0.0125, respectively; P < 0.05). Conclusion: In the IUGR fetuses, significantly thinner insular cortex and temporal lobe cortex and smaller WBA were found compared to the control group. Among different brain regions, the cerebellum and the hippocampus were less affected by growth restriction in the antenatal period. |
| Databáze: | OpenAIRE |
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