Ontogeny of cerebral and ocular prostanoids and prostanoid receptors: biological and clinical significance in the perinatal period
| Autor: | Sylvain Chemtob, Krishna G. Peri, Pierre Hardy, Ding-You Li, Daniel Abran, Daya R. Varma, Mousumi Bhattacharya |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
biology Ontogeny Prostanoid Retinal Nitric oxide synthase chemistry.chemical_compound Cerebral circulation Endocrinology chemistry Cerebral blood flow Internal medicine Pediatrics Perinatology and Child Health medicine biology.protein lipids (amino acids peptides and proteins) Clinical significance sense organs Receptor |
| Zdroj: | Seminars in Neonatology. 3:119-126 |
| ISSN: | 1084-2756 |
| DOI: | 10.1016/s1084-2756(98)80029-8 |
| Popis: | There exists abundant evidence that prostanoids are important messengers involved in a vast array of biological processes. Recent data suggest those prostanoids exert different roles in the regulation of cerebral and ocular circulation of the newborn compared to the adult. Not only are there ontogenic differences in the cerebral and ocular concentrations of prostanoids, which are higher in the newborn than in the adult, but also their receptor-mediated actions differ with age. Understanding of developmental changes in the characterization and regulation of prostanoid receptors on the cerebral and ocular vasculature sheds significant light on mechanisms that control brain and retinal circulation. In this paper, the results of investigation on ontogeny and developmental regulation of prostanoid receptors and their impact on nitric oxide synthase activity on cerebral and ocular vasculature are reviewed. |
| Databáze: | OpenAIRE |
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