The possibility to use multi-walled carbon nanotubes as a sorbent for dispersive solid phase extraction of selected pharmaceuticals and their metabolites: Effect of extraction condition

Autor: Tomasz Puzyn, Klaudia Godlewska, Monika Paszkiewicz, Aleksandra Jakubus, Maciej Gromelski, Karolina Jagiello, Piotr Stepnowski
Rok vydání: 2019
Předmět:
Zdroj: Microchemical Journal. 146:1113-1125
ISSN: 0026-265X
DOI: 10.1016/j.microc.2019.02.051
Popis: This article presents a dispersive solid phase extraction (dSPE) method combined with liquid chromatography-chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) for the simultaneous isolation and quantification of eight pharmaceuticals and their selected metabolites (metronidazole, sulfamethoxazole, N-acetylsulfamethoxazole, diclofenac, 4-hydroxydiclofenac, 5-hydroxydiclofenac, naproxen and 6-O-desmethylnaproxen) in environmental water samples. Interestingly, in the developed method, multi-walled carbon nanotubes (MWCNTs) were used as a sorbent due to their extraordinary sorption capacity. Key parameters that influence the efficiency of the analytical extraction procedure, such as the type and amount of sorbent, the pH of the sample solution and the composition and volume of the elution solvent have been determined. Significant differences in sorption affinity were observed depending on the pH of the sample. To explain these differences, a computational study was carried out to examine the effect of environmental conditions (different pH levels) on the geometry of the structures sulfamethoxazole, N-acetylsulfamethoxazole, diclofenac (described by the variety of structural properties). It is worth noting that only 4 mg of CNTs (with outer diameter
Databáze: OpenAIRE
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