A severe outbreak of haemorrhagic colitis and haemolytic uraemic syndrome associated withEscherichia coli 0157: H7 in Japan
| Autor: | Shunji Akashi, Kohsuke Joh, Takeshi Mori, Atsutoshi Tsuji, Hiroshi Ito, Hiroyuki Hoshi, Takashi Hayakawa, Jiro Ihara, Tsuneyasu Abe, Masayuki Hatori, Taizo Nakamura, S. Akashi |
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| Rok vydání: | 1994 |
| Předmět: |
Hemolytic anemia
medicine.medical_specialty Abdominal pain business.industry Outbreak Disease urologic and male genital diseases medicine.disease Gastroenterology Asymptomatic female genital diseases and pregnancy complications Diarrhea El Niño hemic and lymphatic diseases Internal medicine Pediatrics Perinatology and Child Health Immunology medicine Colitis medicine.symptom business |
| Zdroj: | European Journal of Pediatrics. 153:650-655 |
| ISSN: | 1432-1076 0340-6199 |
| DOI: | 10.1007/bf02190685 |
| Popis: | In 1990, an outbreak ofEscherichia coli 0157: H7 infection occurred in 174 children in a nursery school in Saitama, Japan. The organism was isolated from tap water supplied from the well in the school. Clinical manifestations varied from asymptomatic infection to non-bloody diarrhoea, haemorrhagic colitis, haemolytic uraemic syndrome (HUS) and death. Among culture-confirmed 42 cases ofE. coli 0157: H7, 7 children were asymptomatic, 21 children had only diarrhoea, and 14 children developed HUS. Bloody diarrhoea with abdominal pain following initial frequent diarrhoea appeared to be associated with subsequent HUS. In patients with HUS, both leucocyte count and lactate dehydrogenase activity continued to increase in the early phase of the disease, and on day 3 of illness attained markedly higher levels than in patients without HUS. These two parameters seemed to be important as predictors of the development of HUS. |
| Databáze: | OpenAIRE |
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