The Association of Hypolipidemia and Hyperlipidemia with Non-Alcoholic Fatty Liver Disease in Obese Children
| Autor: | Zeynep Ertürk, Birgül Kirel, Murat Yağcı, Hilmi Onur Kabukçu, İlhan Hazer, Gonca Kılıç Yıldırım |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Lipid Metabolism Disorder business.industry Fatty liver Lipid metabolism 030204 cardiovascular system & hematology medicine.disease Gastroenterology Obesity 03 medical and health sciences Liver disease 0302 clinical medicine Insulin resistance Internal medicine Pediatrics Perinatology and Child Health Hyperlipidemia medicine 030211 gastroenterology & hepatology business Lipoprotein |
| Zdroj: | Türk Pediatri Arşivi. |
| ISSN: | 1306-0015 |
| Popis: | Aim Obesity, insulin resistance, and hyperlipidemia have been shown as risk factors for non-alcoholic fatty liver disease. In this study, the association between lipid and lipoprotein metabolism abnormalities and the presence of non-alcoholic fatty liver disease was investigated in patients with obesity. Material and methods In this study, the clinical, laboratory and imaging findings of 357 children and adolescent patients (199 girls and 158 boys) aged 2-18 years who were diagnosed as having obesity between 2013 and 2018 were retrospectively analyzed. The clinical and laboratory features of the patients who were diagnosed as having non-alcoholic fatty liver disease using ultrasonography were compared with patients who did not have non-alcoholic fatty liver disease. All lipid and lipoprotein levels were defined as hypo-, normo- and hyperlipidemic in comparison with the reference values according to age and sex. Results The frequency of non-alcoholic fatty liver disease was 44.5% in the entire study group and was higher in males (p 0.05). The frequency of lipid metabolism disorder (hypolipidemia and/or hyperlipidemia) was found as 77.5% in all patients. Conclusion Non-alcoholic liver disease and lipid metabolism disorders are common in children and adolescents with obesity. The frequency of non-alcoholic fatty liver disease in hypolipidemic, normolipidemic, and hyperlipidemic patients was not different. This finding indicated that the increase in the amount of body fatty tissue and insulin resistance were more important risk factors in the development of non-alcoholic fatty liver disease. |
| Databáze: | OpenAIRE |
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