Churg-Strauss Syndrom: Necessity Points in the Diagnosis and Treatment
| Autor: | Toshiya Katsumata, Genki Mizukoshi, Daisuke Takada, Yasuhiko Iino, Tomohiro Kaneko, Chisako Kamano, Yuko Fujita, Ken-ichiro Katsura, Yasuo Katayama, Syoichiro Kijima, Kouichi Utsumi, Kae Ueda |
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| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Nihon Ika Daigaku Igakkai Zasshi. 1:21-25 |
| ISSN: | 1880-2877 1349-8975 |
| DOI: | 10.1272/manms.1.21 |
| Popis: | A 32-year-old man with a history of adult-onset asthma and a high level of P-ANCA and eosinophilia was referred to our hospital because of renal insufficiency. Renal and skin biopsy specimens confirmed a diagnosis of Churg-Strauss Syndrome (CSS). Treatment with steroid therapy alone including methylprednisolone pulse therapy was unsatisfactory, so additional treatment with cyclophosphamide was started. Three days later, he presented with convulsions and consciousness disturbance. MRI of the brain demonstrated bilateral whitematter abnormality that was characteristic of reversible posterior encephalophathy syndrome (RPES). Since the activity of CSS was still high, immunosuppressive therapy was continued combined with antihypertensive therapy. His consciousness was soon recovered and MRI findings improved later. RPES is an uncommon complication of CSS. In this case RPES might have been associated with CNS vasculitis. |
| Databáze: | OpenAIRE |
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