EVALUATING UTILITY OF PROTEIN S100A7 IN PREDICTING PROGRESSION OF ORAL EPITHELIAL DYSPLASIA

Autor: Art F. Y. Poon, Jerrold E. Armstrong, Lachlan McLean, Mark R. Darling, Linda Jackson
Rok vydání: 2019
Předmět:
Zdroj: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 128:e75
ISSN: 2212-4403
DOI: 10.1016/j.oooo.2019.02.185
Popis: Objectives Protein biomarker, S100A7, in oral dysplasia and squamous cell carcinoma has shown some predictive value for the transformation of dysplasia to cancer. The objectives of this study are: (1) to determine a correlation between the expression of S100A7 and histologic grade of oral dysplastic lesions using immunohistochemistry and an algorithm based on image analysis; and (2) to evaluate whether S100A7 can be utilized as a reliable predictor for progression of low grade oral dysplastic lesions or transformation to carcinoma. Findings 8 low grade lesions evolved into high grade lesions, and 7 high grade lesions evolved into higher grade lesions, over time. For the low grade lesions, the average S100A7 immunostaining score was 5.6; three were graded low risk and 5 were graded medium risk by algorithm. One low grade and 3 high grade lesions did not progress and remained stable. For these, the average S100A7 immunostaining score was 5.8; one was graded low risk and 3 were graded medium risk by algorithm. Preliminary analysis suggests S100A7 has increased expression in higher risk lesions. Conclusion The identification of a reliable, quantitative measure in the diagnosis of dysplasia and the ability to predict the likelihood of transformation to malignancy will potentially lead to more individualized treatment and better patient outcomes.
Databáze: OpenAIRE
Externí odkaz: