High level of low density lipoprotein cholesterol in younger children of patients with premature coronary artery disease: relation to own and parental risk factors
| Autor: | A.D. Deev, M.V. Konov, N.A. Gratsiansky |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Proband
medicine.medical_specialty Univariate analysis Waist business.industry medicine.disease Endocrinology Blood pressure Internal medicine Diabetes mellitus medicine lipids (amino acids peptides and proteins) Metabolic syndrome Cardiology and Cardiovascular Medicine business Body mass index Breast feeding |
| Zdroj: | European Heart Journal. 34:P703-P703 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/eht307.p703 |
| Popis: | High level of low density lipoprotein cholesterol (LDL-C) is a critical contributor to coronary risk in children of patients with premature coronary artery disease (PCAD). Purpose: To elucidate associations between high LDL-C in children of patients with PCAD (onset ≤55 years, men; ≤60 years, women) and some their own and parental characteristics. Methods: We examined members of 122 families with children aged 5-17 years: 111 parents-probands (83.8% men, aged 32-56 years, 84.7% after MI), their 103 consorts (12.6% men, aged 28-63 years, 1% with overt CAD) and 152 their own children (63.2% men, aged 5-17 years). We registered weight at birth, breast feeding duration, habits, body mass index (BMI), waist circumference (WC), heart rate (HR), systolic (S)/diastolic BP, total/high density lipoprotein (HDL) C, LDL-C, triglycerides (TG), glucose, glucose tolerance, diabetes, arterial pre-/hypertension (NHBPEP-4 criteria) and (in parents) education, menstruation status, metabolic syndrome (MS, JIS criteria). In persons aged 5-17 years high LDL-C was defined as ≥90 percentile (Lipid Research Clinics). Predictors of high LDL-C were selected by age, sex adjusted logistic regression. Results: High LDL-C was found in 42/152 (27.6%) of children. Characteristics related to the presence of high LDL-C with p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|