| Popis: |
The liver is the largest gland in the body and performs hundreds of vital functions, most of which are carried out by the hepatocytes that constitute about 80% of the liver's total cell population. Besides being the main organ for a variety of vital functions, the liver is the best example of an organ that possesses major regenerative capacity following partial hepatectomy or toxic injury. The adaptive response and robustness of liver regeneration is critical to ensure the body's metabolic functions, and liver disease may have a profound negative impact on metabolism and homeostasis of the body. As a result, therapies that ensure some degree of recovery from liver disease are greatly sought worldwide. Herein, we describe some of the most common liver diseases and numerous novel regenerative therapies in development or already translated into the clinic, that rely on liver regeneration. |
