Novel method for the synthesis of lenvatinib using 4-nitrophenyl cyclopropylcarbamate and their pharmaceutical salts
| Autor: | Sireesha Malladi, Rajesh Kumar Rapolu, Naveen Mulakayala, V.V.N.K.V. Prasada Raju, N. Srinivasu, Ravi Kumar Sadineni |
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| Rok vydání: | 2020 |
| Předmět: |
Chemistry
General Chemical Engineering Synthon 02 engineering and technology General Chemistry Chloroformate 010402 general chemistry 021001 nanoscience & nanotechnology Phosphate 01 natural sciences Biochemistry Anticancer drug Combinatorial chemistry Industrial and Manufacturing Engineering Oxalate 0104 chemical sciences chemistry.chemical_compound Materials Chemistry Amine gas treating 0210 nano-technology Acetonitrile Lenvatinib |
| Zdroj: | Chemical Papers. 75:1475-1483 |
| ISSN: | 1336-9075 2585-7290 |
| Popis: | 4-Nitrophenyl cyclopropylcarbamate was deployed as a novel synthon for the synthesis of anticancer drug lenvatinib. 4-Nitrophenyl cyclopropylcarbamate was prepared by the reaction of 4-nitrophenyl chloroformate and cyclopropyl amine in acetonitrile at room temperature. Furthermore, lenvatinib was synthesized by reacting 4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide with 4-nitrophenyl cyclopropylcarbamate in good yields. Apart from the synthesis of lenvatinib, citrate, phosphate, malate and oxalate salts of lenvatinib were also reported in good yields. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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