Synthesis of 4-aryloxy-7-nitrobenzofurazan derivatives from 4-chloro-7-nitrobenzofurazan and various phenoxide anions (including pharmaceuticals) in the presence of crown ethers

Autor:	Alexandru T. Balaban, Titus Constantinescu, Miron Teodor Caproiu, Marioara Bem, Dan Stoicescu
Rok vydání:	2003
Předmět:	General Chemistry 4-Chloro-7-nitrobenzofurazan Medicinal chemistry Eugenol NMR spectra database chemistry.chemical_compound Isoeugenol Betaine chemistry Materials Chemistry Nucleophilic substitution Organic chemistry Phenol Guaiacol
Zdroj:	Open Chemistry. 1:260-276
ISSN:	2391-5420
Popis:	4-Chloro-7-nitrobenzofurazan reacts by nucleophilic substitution with phenoxide anions derived from estriol (2c), ethynylestradiol (2d), phenol (3e), guaiacol (3f), 2,6-dimethoxyphenol (3g), eugenol (3h), isoeugenol (3i), the cytostatic Etoposide (4), and Reichardt’s betaine (5) in the presence of crown ethers affording the corresponding 4-aryloxy-7-nitrobenzofurazan derivatives 6c, 6d, 7e-7i, 8, and 9. The structure of these compounds was confirmed by NMR spectra. Hydrophobicity/hydrophilicity parameters were investigated by reverse phase thin-layer chromatography.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bfff92af1b45b21feba8e46724b6f44f https://doi.org/10.2478/bf02476228 Zobrazit plný text záznamu