An alternative synthesis of temafloxacin, a potent antibacterial agent

Autor:	Hermann Faubl, Daniel T. W. Chu, Isabella M. Lico, Akiyo K. Claiborne
Rok vydání:	1992
Předmět:	Hydrochloride Organic Chemistry Temafloxacin General Chemistry Combinatorial chemistry Catalysis chemistry.chemical_compound chemistry Nucleophile Intramolecular force medicine Displacement (orthopedic surgery) medicine.drug Antibacterial agent Acetophenone
Zdroj:	Canadian Journal of Chemistry. 70:1323-1327
ISSN:	1480-3291 0008-4042
DOI:	10.1139/v92-170
Popis:	An alternative synthesis of (±)-7-(3-methylpiperazin-1-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride 4, a potent antibacterial agent, was developed. The method was characterized by regiospecific displacement of the 4-fluoro of the 2,4,5-trifluoroacetophenone by 2-methylpiperazine to produce the key intermediate, 2,5-difluoro-4-(3-methylpiperazin-1-yl)acetophenone 12, which was subsequently converted to 4 via an intramolecular nucleophilic displacement cyclization reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bff31a68d81810d63bf6d5efcd0663de https://doi.org/10.1139/v92-170 Zobrazit plný text záznamu