Hepatitis C virus genotypes: epidemiological and clinical associations
| Autor: | Michael Adler, R. A. Heijtink, Jacques Versieck, Frederik Nevens, Nadine Bourgeois, L. van Doorn, Wjc Hop, Wgv Quint, Bernhard Kleter, R Brenard, Hautekeete M, André Elewaut, Johannes T. Brouwer, CM Bronkhorst, Solko W. Schalm, Rafm Chamuleau, J. Fevery, P.P. Michielsen |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Hepatology biology business.industry Hepatitis C virus Hepacivirus Hepatitis B medicine.disease medicine.disease_cause Chronic liver disease biology.organism_classification Gastroenterology Liver disease Flaviviridae Internal medicine Immunology medicine Viral disease business |
| Zdroj: | Liver. 18:32-38 |
| ISSN: | 0106-9543 |
| DOI: | 10.1111/j.1600-0676.1998.tb00124.x |
| Popis: | — In a cohort of 292 chronic hepatitis C patients living in the Benelux countries the relationship between viral genotype and geographical origin, route of transmission, clinical characteristics and severity of liver disease was analyzed. HCV-RNA isolates could be classified by the Line Probe Assay (LiPA) as 1a, 1b, 2, 3, 4 or 5 in 286 (98%) cases. Patients of European origin were predominantly infected with HCV subtype 1b (164/254, 65%, CI 58–70%), as were patients of Asian origin (7/13, 54%). Patients originating from Surinam (South America) had predominantly type 2 (9/10, 90%), whereas Africans were mainly infected with type 4 (7/9, 77%). Blood transfusion was the mode of transmission in 142 (50%) patients, intravenous drug abuse (IVDA) in 40 (14%), occupational needle accident or tattoo in 11 (4%); no obvious source of infection was found in 93 (33%). In patients infected by blood transfusion, subtype 1b was predominant (70%, CI 61–77%), whereas subtypes 1a and 3 were predominant in those infected by IVDA (25% and 45%, respectively, p |
| Databáze: | OpenAIRE |
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