Influence of Hydralazine Treatment on the Vascular Reactivity of DOCA-Salt Hypertensive Rats

Autor:	Z. B. Fortes, Regina Scivoletto, Dorothy Nigro, M. H. C. Carvalho, R. K. N. Cuman
Rok vydání:	1994
Předmět:	Treated group medicine.medical_specialty Endothelium Physiology business.industry Cell Biology General Medicine Hydralazine Doca salt Treatment period Vascular reactivity Endocrinology medicine.anatomical_structure Internal medicine medicine Sodium nitroprusside business Acetylcholine medicine.drug
Zdroj:	Endothelium. 2:105-111
ISSN:	1029-2373 1062-3329
DOI:	10.3109/10623329409024639
Popis:	To investigate if anti-hypertensive drug therapy is effective in correcting the altered endo-thelial responses observed in blood vessels of DOCA-salt hypertensive rats, cumulative concentration-effect curves to noradrenaline, acetylcholine and sodium nitroprusside were constructed in rings of thoracic aortas with or without endothelium isolated from DOCA-salt hypertensive and control rats treated with hydralazine for 24 h (acute) or 15 d (chronic). Effective concentrations (EC50s) and maximal responses were analysed. Blood pressures of both control and DOCA-salt hypertensive rats decreased within 24 h to levels at or below those obtained before treatment and were maintained at reduced levels during the remainder of the treatment period (15 d). In preparations with endothelium, lower EC50s for noradrenaline were observed in aortas from DOCA-salt hypertensive rats in comparison with corresponding controls except for hydralazine (15 d) -treated group. The maximal responses to noradrenaline did not differ sig...
Databáze:	OpenAIRE
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