Emergence of Carbapenemase-Producing Enterobacteriaceae, South-Central Ontario, Canada1
| Autor: | Brenda L. Coleman, Shumona Shafinaz, Jeff Powis, Andrew E. Simor, Irene Armstrong, Sergio Borgia, Freda Lam, Matthew P. Muller, Allison McGeer, Samir N. Patel, Karen Green, Jennie Johnstone, Susan M. Poutanen, Kevin Katz, Philipp Kohler, Alicia Sarabia, Roberto G. Melano, Anu Rebbapragada, Emily Borgundvaag, Huda Almohri, David B. Richardson, Amna Faheem |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Epidemiology Klebsiella pneumoniae 030106 microbiology Population Carbapenem-resistant enterobacteriaceae Drug resistance 03 medical and health sciences 0302 clinical medicine Antibiotic resistance medicine 030212 general & internal medicine education education.field_of_study biology Transmission (medicine) business.industry Incidence (epidemiology) Medical record biochemical phenomena metabolism and nutrition biology.organism_classification 3. Good health Infectious Diseases Emergency medicine business |
| Zdroj: | Emerging Infectious Diseases. 24:1674-1682 |
| ISSN: | 1080-6059 1080-6040 2007-2015 |
| DOI: | 10.3201/eid2409.180164 |
| Popis: | We analyzed population-based surveillance data from the Toronto Invasive Bacterial Diseases Network to describe carbapenemase-producing Enterobacteriaceae (CPE) infections during 2007-2015 in south-central Ontario, Canada. We reviewed patients' medical records and travel histories, analyzed microbiologic and clinical characteristics of CPE infections, and calculated incidence. Among 291 cases identified, New Delhi metallo-β-lactamase was the predominant carbapenemase (51%). The proportion of CPE-positive patients with prior admission to a hospital in Canada who had not received healthcare abroad or traveled to high-risk areas was 13% for patients with oxacillinase-48, 24% for patients with New Delhi metallo-β-lactamase, 55% for patients with Klebsiella pneumoniae carbapenemase, and 67% for patients with Verona integron-encoded metallo-β-lactamase. Incidence of CPE infection increased, reaching 0.33 cases/100,000 population in 2015. For a substantial proportion of patients, no healthcare abroad or high-risk travel could be established, suggesting CPE acquisition in Canada. Policy and practice changes are needed to mitigate nosocomial CPE transmission in hospitals in Canada. |
| Databáze: | OpenAIRE |
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