Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity

Autor:	Christophe Rochais, Patrick Dallemagne, Jana Sopkova-de Oliveira Santos, Julien Lalut, Pauline Zipfel
Rok vydání:	2021
Předmět:	Scaffold 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Chemical reaction Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Chemical diversity Thiophene Surface modification
Zdroj:	Synthesis. 53:3799-3814
ISSN:	1437-210X 0039-7881
DOI:	10.1055/a-1523-1409
Popis:	Aminothiaindanone heterocycle appears to be a scaffold of interest in medicinal chemistry. To increase the chemical diversity in this series, the introduction of three-point chemical diversity on the cyclopenta[b]thiophen-4-one scaffold was explored. About thirty newly functionalized thiophene-containing bicycles were obtained using various chemical reactions, paving the way for novel possibilities in medicinal chemistry projects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bea733dade18251af18ba7e8a4e2946f https://doi.org/10.1055/a-1523-1409 Zobrazit plný text záznamu