| Autor: | Fatma Kormali, Ahmet Colak, Kerim Serbest, Serdar Karaböcek, Saadettin Güner |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
biology
Stereochemistry Superoxide Ligand Metals and Alloys chemistry.chemical_element Manganese Copper Medicinal chemistry Inorganic Chemistry Metal Superoxide dismutase chemistry.chemical_compound chemistry visual_art Materials Chemistry visual_art.visual_art_medium biology.protein Chelation Organometallic chemistry |
| Zdroj: | Transition Metal Chemistry. 26:625-629 |
| ISSN: | 0340-4285 |
| DOI: | 10.1023/a:1012062510447 |
| Popis: | Novel mononuclear [Cu(HPnAO)H2O]ClO4(2), homodinuclear [Cu(PnAO)Cu(phen)(H2O)2](ClO4)2(3), homotrinuclear [Cu3(PnAO)2(H2O)2](ClO4)2(4) and heterodinuclear [Cu(PnAO)Mn(phen)2(H2O)](ClO4)2(5) complexes have been prepared from 3,3′-(1,3-propanediyldiimine)bis-(3-methyl-2-butanone)dioxime (H2PnAO) and characterized by elemental analyses, magnetic moments, i.r., u.v.–vis., and by mass spectral studies. The geometry of the metal chelates is discussed with the help of magnetic and spectroscopic measurements. I.r. spectra show that the ligand acts in a tetradentate manner and coordinates through the (C=N) and (N—H) groups. The elemental analyses, stoichiometry and the spectroscopic data of the complexes indicate that the copper(II) ions are coordinated by the ligand dianion. The heterodinuclear complex (5) displays in vitro ability to scavenge superoxide radicals produced by the xanthine–xanthine oxidase (XXO) system, using nitroblue tetrazolium as an indicator. The complex also supports aerobic growth of Escherichia coli (sodA−sodB−) in vivo in minimal media, indicating that complex (5) is a speculative potent SOD-mimic. |
| Databáze: | OpenAIRE |
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