Structurally diversified diterpenoids from Euphorbia dracunculoides

Autor:	Fu-Mei Yang, Yong Zhao, Jing Yang, Qian-Yun Sun, Xiang-Hua Wu, Zhen Zang, Xiao-Nian Li, Feng-Yi Liu, Ya-Tuan Ma, Li Wang, Yijun Yan, Sheng-Xiong Huang
Rok vydání:	2015
Předmět:	chemistry.chemical_classification chemistry Phytochemical Stereochemistry Euphorbia dracunculoides Organic Chemistry Drug Discovery Glycoside Moderate activity Cancer cell lines Biochemistry Terpenoid
Zdroj:	Tetrahedron. 71:5484-5493
ISSN:	0040-4020
DOI:	10.1016/j.tet.2015.06.078
Popis:	Extensive phytochemical investigation of the aerial parts of Euphorbia dracunculoides led to the isolation of 19 structurally diversified diterpenoids with five different carbon skeletons, including six new lathyrane glycosides (1-6), three new cyclomyrsinanes (7-9), three new premyrsinanes (10-12), and one new 10,18-dihydromyrsinane (13). Their structures were elucidated by means of extensive spectroscopic analysis, and the structure of 7 was further confirmed by X-ray crystallography. Compounds 1-6 are the first examples of C-17-glycosylated lathyrane diterpenoids. Selected isolates were evaluated for their cytotoxicity against five cancer cell lines. Only the tiglianes exhibited moderate activity. (C) 2015 Elsevier Ltd. All rights reserved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::be2ef5a1d100fd70256e4b028de9a5f4 https://doi.org/10.1016/j.tet.2015.06.078 Zobrazit plný text záznamu Full Text from ScienceDirect