Comparison of Hepatotoxicity of 1,2-, 1,3- and 1,4-Dibromobenzenes: the Dynamics of Changes of Selected Parameters of Liver Necrosis in Acute Poisoning in Mice

Autor:	S. Sporny, E. Bruchajzer, Jadwiga A. Szymańska
Rok vydání:	1996
Předmět:	medicine.medical_specialty Necrosis Ratón Glutathione Toxicology Malondialdehyde Acute toxicity Transaminase Liver necrosis chemistry.chemical_compound Endocrinology Biochemistry chemistry Internal medicine Toxicity medicine medicine.symptom
Zdroj:	Journal of Applied Toxicology. 16:35-41
ISSN:	1099-1263 0260-437X
DOI:	10.1002/(sici)1099-1263(199601)16:1<35::aid-jat307>3.0.co;2-t
Popis:	Various doses of dibromobenzene isomers (1,2-dBB, 1,3-dBB, 1,4-dBB) were administered (i.p.) to BALB mice. The levels of reduced glutathione (GSH) and malondialdehyde (MDA) in the liver, and glutamate-pyruvate transaminase (GPT) (EC.2.6.1.2) gamma-glutamyltransferase (gamma-GT) (EC.2.3.2.2) and triglycerides (TG) in the serum were estimated. A considerable decrease of GSH was observed between 2 and 12 h after administration of the compounds. Increases in serum GPT activity (up to 100-fold) and gamma-GT (three-to fivefold) were observed after treatment using 1,2- and 1,3-dibromobenzenes; TG decreased in concentration initially and then slightly increased. Histopathological examination confirmed the strong necrotic effect of 1,2- and 1,3-dBB isomers. No such changes (elevation of serum GPT activity and necrosis) were noticed after 1,4-dBB.
Databáze:	OpenAIRE
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