Abstract P063: Pressor Response To Acute Stress Is Regulated By Histamine In Humanized Sickle Cell Mice

Autor:	David M. Pollock, Malgorzata Kasztan, Bryan K. Becker, Patrick Molina, Brandon M. Fox, Davide Botta, John Miller Allan, Randee Sedaka, Jennifer S. Pollock
Rok vydání:	2020
Předmět:	business.industry Vascular disease Cell Disease medicine.disease chemistry.chemical_compound medicine.anatomical_structure Pressor response chemistry Psychosocial stress Immunology Internal Medicine medicine In patient Acute stress business Histamine
Zdroj:	Hypertension. 76
ISSN:	1524-4563 0194-911X
Popis:	Acute psychosocial stress has been linked to the onset of vaso-occlusive pain crises in patients with sickle cell disease (SCD), however mechanistic insight is lacking. Studies suggest that histamine is a stress-responsive factor and promotes inflammation. In SCD, histamine levels are elevated in association with vaso-occulsive crisis, however, the impact of acute stress is unknown. We hypothesized that acute stress in a humanized SCD mouse model stimulates the histamine pathway, inflammatory mediator release, and a pressor response. Acute stress was induced using cage switch stress (CSS) in male humanized SCD (HbSS) or control (HbAA) mice (n=6-8/group) with blood pressure (BP) monitored by radiotelemetry and mice terminated at baseline (BL, no CSS) and 30 min post-CSS for plasma measurements. Plasma histamine was unchanged in HbAA mice but was elevated in HbSS in response to CSS (nM; HbAA: 90.2±21.3; 104.3±10.2; HbSS: 91.1±13.6; 174.3±19.2*, *pgenotype =0.0001, *pgenotype genotype
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bdef1137f47cdf7b562d222d1811c5b5 https://doi.org/10.1161/hyp.76.suppl_1.p063 Zobrazit plný text záznamu