Synthesis of an azaspirane via Birch reduction alkylation prompted by suggestions from a computer program

Autor:	Malcolm Bersohn, Tetsuhiko Takabatake, Takashi Kawai, Akio Tanaka, Noriko Oka, Hideho Okamoto
Rok vydání:	2006
Předmět:	chemistry.chemical_compound Birch reduction chemistry Azaspirane Organic Chemistry Drug Discovery Lactam Organic chemistry Amine gas treating Alkylation Biochemistry Retrosynthetic analysis Benzoic acid
Zdroj:	Tetrahedron Letters. 47:6733-6737
ISSN:	0040-4039
Popis:	With the aid of proposals from a computer program for synthesis design, a new method of synthesizing azaspiranes has been developed. In this method, one starts with a suitable benzoic acid ester, which is subjected to Birch reduction. Then the anionic intermediate is alkylated with 1,2-dibromoethane. The product is subsequently reacted with an amine to give a spiro lactam.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bda0308ca70941923608d9fc4f67c1f6 https://doi.org/10.1016/j.tetlet.2006.07.100 Zobrazit plný text záznamu Full Text from ScienceDirect