Synthesis of an azaspirane via Birch reduction alkylation prompted by suggestions from a computer program
Autor: | Malcolm Bersohn, Tetsuhiko Takabatake, Takashi Kawai, Akio Tanaka, Noriko Oka, Hideho Okamoto |
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Rok vydání: | 2006 |
Předmět: | |
Zdroj: | Tetrahedron Letters. 47:6733-6737 |
ISSN: | 0040-4039 |
Popis: | With the aid of proposals from a computer program for synthesis design, a new method of synthesizing azaspiranes has been developed. In this method, one starts with a suitable benzoic acid ester, which is subjected to Birch reduction. Then the anionic intermediate is alkylated with 1,2-dibromoethane. The product is subsequently reacted with an amine to give a spiro lactam. |
Databáze: | OpenAIRE |
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