Einfluß von Ticlopidin auf die periphere obliterierende Arteriopathie

Autor:	Mietaschk A, H J Trampisch, Ingrisch H, H. Hess, H Stiegler
Rok vydání:	2008
Předmět:	medicine.medical_specialty medicine.diagnostic_test business.industry General Medicine Arteriosclerosis Placebo medicine.disease law.invention Peripheral Clinical trial Randomized controlled trial law Internal medicine Angiography medicine Cardiology Platelet Ticlopidine business medicine.drug
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 109:1240-1243
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1069356
Popis:	The efficacy of and tolerance to ticlopidine, a platelet inhibitor, in preventing progression of obliterative arterial disease was compared with that of a placebo in a double-blind and randomized trial in 43 patients (22 on placebo, 21 on ticlopidine) over a period of one year. The course of the disease in both groups was assessed by serial angiography of the lower limbs, both at the beginning and at the end of the study. There was a significantly reduced progression in the ticlopidine group (P less than 0.01). The results support the hypothesis that platelets are of great importance in the progression of arteriosclerosis and that inhibition of platelet function is an effective principle of prevention. Ticlopidine in this respect is an alternative to the use of acetylsalicylic acid.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bd601af4b8834a3d1ff283524898b637 https://doi.org/10.1055/s-2008-1069356 Zobrazit plný text záznamu