Scan-Time Corrections for 80–100-min Standardizetd Uptake Volume Ratios to Measure the 18F-AV-1451 Tracer for Tau Imaging
| Autor: | William J. Jagust, Mark He, Samuel N. Lockhart, Suzanne L. Baker, Vyoma D. Shah |
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| Rok vydání: | 2019 |
| Předmět: |
Offset (computer science)
Radiological and Ultrasound Technology business.industry Standardized uptake value Iterative reconstruction Residual Least squares 030218 nuclear medicine & medical imaging Computer Science Applications Weighting 03 medical and health sciences 0302 clinical medicine TRACER Electrical and Electronic Engineering Nuclear medicine business Software Interpolation Mathematics |
| Zdroj: | IEEE Transactions on Medical Imaging. 38:697-709 |
| ISSN: | 1558-254X 0278-0062 |
| DOI: | 10.1109/tmi.2018.2870441 |
| Popis: | The 18F-AV-1451 PET tracer binds to tau, an Alzheimer’s disease biomarker. The standardized uptake value ratio (SUVR) 80–100 min window is widely used to quantify tau binding, although 18F-AV-1451 continues increasing relative to a reference region in regions with tau deposition. Left uncorrected, acquisition time inaccuracies can lead to errors from −4% to 6% in 20-min SUVR measurements in subjects with Alzheimer’s disease. In 40 subjects with scans from 75–115 min following 18F-AV-1451 injection, we created 20-min reconstructions ( $4\times 5$ min) of start-times ranging from 75–85 min, as proxies of offset scans and calculated the mean in regions of interest (ROIs). We developed a segmented least squares (SLS) method to obtain error-minimizing weighting coefficients for 18F-AV-1451 ROIs that best predict SUVR 80–100 from weighted means of SUVRs from offset start-times. We compared residual errors of our SLS method to those in: 1) uncorrected offset 20-min-SUVRs; 2) the mean of five-min frames within the 80–100 window; and 3) a least-squares interpolation method. We evaluated errors induced by start-time offset on SUVRs for each method. The SLS, which corrected using least-squares coefficients of 5-min components, consistently reduced errors across all offset start-times. Effect size analysis for simulated clinical longitudinal 18F-AV-1451 drug trials showed that uncorrected 20-min offset SUVRs would require up to 20% more participants to detect treatment effects compared with using SLS. Correction of SUVR scan-time errors by SLS minimizes errors compared with other correction methods and may be extended to other scanners and tracers. |
| Databáze: | OpenAIRE |
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