Disposition of Dehydroepiandrosterone and Its Sulfate in Human Subject1
| Autor: | Mary Jane Burgett, Avery A. Sandburg, W. Roy Slaunwhite |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Urinary system Biochemistry (medical) Clinical Biochemistry Biliary fistula Dehydroepiandrosterone medicine.disease Biochemistry Intestinal absorption chemistry.chemical_compound Endocrinology Dehydroepiandrosterone sulfate chemistry Internal medicine medicine Ingestion Sulfate Testosterone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 27:663-670 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-27-5-663 |
| Popis: | The disposition of 4-14C dehydroepiandrosterone (D) and 7α-3H dehydroepiandrosterone sulfate (DS) (3H/14C =5.0) was studied in 11 subjects, 5 of whom had biliary fistulas. The mixture of D and DS was injected intravenously in 9 subjects and taken orally by 2 subjects. About 2% of 14C appeared in the bile, whereas 11% of 3H was excreted by that route. Urinary excretion in intact subjects was 45% of the 14C and 55% of the 3H. The total recovery of radioactivity was the same in all groups, indicating intestinal absorption of D and DS. This conclusion was confirmed by the results of oral ingestion, which closely resembled those following intravenous administration. The 3H/14C ratio of urinary testosterone glucosiduronide was initially 1/10 of that injected, suggesting that of the 2 steroids administered DS is a poorer precursor of testosterone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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