Efficient Synthesis of Functionalized 3-Aminopropanols

Autor: Shan Shan Gong, Xiao Chuan Li, Qi Sun
Rok vydání: 2014
Předmět:
Zdroj: Applied Mechanics and Materials. 662:67-70
ISSN: 1662-7482
DOI: 10.4028/www.scientific.net/amm.662.67
Popis: A series of α-aminophosphonate-functionalized 3-aminopropanols have been efficiently prepared and characterized by1H,13C, and31P NMR and mass spectroscopy. The reaction conditions such as solvent and temperature were thoroughly investigated based on the three-component Kabachnik-Fields reaction. The experimental results revealed that moderate elevation of reaction temperature under solvent-free conditions was optimal for the synthesis of these types of compounds without forming the cyclized byproduct.
Databáze: OpenAIRE