| Autor: |
Helen R. Griffiths, Stuart J. Bennett, Irundika H.K. Dias, Justin W. Killick, Christopher R. Dunston |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Immunology of Aging ISBN: 9783642394942 |
| DOI: |
10.1007/978-3-642-39495-9_4 |
| Popis: |
The ageing process results from a complex interplay between genes and the environment that can precipitate an uncontrolled inflammation. Epigenetic changes are believed to provide a link between the environment and nutrition to gene expression by altering the activity of some histone-modifying protein. Epigenetic modifications of DNA and histone proteins have been proposed as important contributory mechanisms to the retention of metabolic memory over time. A thorough understanding of the posttranscriptional and epigenetic factors involved in both normal ageing and age-related disease may inform new strategies and approaches to diagnose, treat, or suppress many aspects of age-dependent frailty. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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