Diastereoselective sulfonate-directed carbonyl reduction of γ-keto-sulfonates

Autor:	Mauro F. A. Adamo, Francesco Alletto, Andrea Ravelli, Colm Duffy, Malachi W. Gillick-Healy, Noel McLaughlin, Stefano Lancianesi
Rok vydání:	2019
Předmět:	010405 organic chemistry Hydride Organic Chemistry Carbonyl reduction 010402 general chemistry Boron atom 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Sulfonate chemistry Drug Discovery Chelation
Zdroj:	Tetrahedron Letters. 60:1313-1316
ISSN:	0040-4039
Popis:	The diastereoselective reduction of γ-keto-sulfonates to afford α,γ-substituted γ-hydroxy sulfonates has been investigated. Herein we report the first example of a diastereoselective carbonyl reduction whereby hydride attack is directed via chelation of a neighbouring sulfonate group to a boron atom, thus affording prevalently trans γ-hydroxy sulfonates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bc2948a7385226c76d8025ac7d310a2d https://doi.org/10.1016/j.tetlet.2019.03.065 Zobrazit plný text záznamu Full Text from ScienceDirect